Leff D R, Nortley M, Dang Van, Bhutiani R P
Department of Biosurgery and Surgical Technology, Imperial College, London, UK.
Anaesthesia. 2007 Jul;62(7):677-82. doi: 10.1111/j.1365-2044.2007.05056.x.
The effect of pre-infiltration local cooling of the site of inguinal herniorrhaphy on pain perception during infiltration of local anaesthetic was studied in a prospective randomised controlled trial. One hundred patients were randomly allocated to receive topical application of either a cooled saline bag (study group) or a saline bag at room temperature (control group) prior to injection of local anaesthetic. Pain scores were recorded using a visual analogue scale following application of the saline bags and again on completion of infiltration with local anaesthetic. There was no significant difference in pain scores following topical saline bag application. However, a highly significant difference (p = 0.0001, Mann-Whitney U) was observed between post-infiltration pain scores of the study group (median = 2) and the control group (median = 6).
在一项前瞻性随机对照试验中，研究了腹股沟疝修补术部位预浸润局部冷却对局部麻醉药浸润过程中疼痛感知的影响。100例患者在注射局部麻醉药前被随机分配接受局部应用冷却盐袋（研究组）或室温盐袋（对照组）。在应用盐袋后以及局部麻醉药浸润完成后，使用视觉模拟量表记录疼痛评分。应用盐袋后的疼痛评分无显著差异。然而，研究组（中位数 = 2）和对照组（中位数 = 6）浸润后疼痛评分之间观察到高度显著差异（p = 0.0001，曼-惠特尼U检验）。
