滥用多塞平诱发躁狂症。
Abuse of dosulepin to induce mania.
作者信息
Lepping Peter, Menkes David B
机构信息
North Wales Section of of Psychological Medicine, University of Wales Academic Unit, Wrexham, Wales.
出版信息
Addiction. 2007 Jul;102(7):1166-7. doi: 10.1111/j.1360-0443.2007.01828.x.
BACKGROUND
Tricyclic antidepressants sometimes trigger mania in bipolar patients, but little is known about their potential for abuse in this regard.
CASE DESCRIPTION
We describe a man with bipolar disorder and alcohol dependency who abused dosulepin repeatedly in order to induce manic episodes. This caused serious problems for treatment and long-term outcome. We mention two further cases in which dosulepin or clomipramine was used deliberately to induce bipolar mania.
CONCLUSIONS
Tricyclic antidepressants can be abused to induce mood elevation in bipolar patients. This should be considered in cases of treatment-resistant mania.
背景
三环类抗抑郁药有时会引发双相情感障碍患者的躁狂发作，但在这方面其滥用潜力鲜为人知。
病例描述
我们描述了一名患有双相情感障碍和酒精依赖的男性，他反复滥用多塞平以诱发躁狂发作。这给治疗和长期预后带来了严重问题。我们还提及另外两例故意使用多塞平或氯米帕明诱发双相躁狂的病例。
结论
三环类抗抑郁药可被滥用以使双相情感障碍患者情绪高涨。在难治性躁狂病例中应考虑到这一点。
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