Kobayashi Makoto, Yamamoto Masayuki
Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences; ERATO Environmental Response Project, Japan Science and Technology Agency, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
J Biochem. 2007 Jul;142(1):1-10. doi: 10.1093/jb/mvm122. Epub 2007 Jun 13.
GATA1 is one of the most fascinating transcription factors for biologists. It regulates many haematopoietic genes and interacts with a number of other transcription factors. Its functions are mostly conserved among vertebrates. Upon disruption of the GATA1 gene, mice show a drastic bloodless phenotype. GATA1 knockdown mice are predisposed to tumour development, the extent of which varies depending on the level of knockdown. When GATA1 is overexpressed, certain cells face an altered cell fate. These observations suggest the importance of regulation on the expression level and timing of GATA1. Deciphering such regulation is the key to understanding the commitment and differentiation of blood cells. There are so many splendid reviews describing GATA1 as a transcription factor. We therefore focus our topics on GATA1 gene regulation in this review.
GATA1是生物学家们最感兴趣的转录因子之一。它调控许多造血基因，并与许多其他转录因子相互作用。其功能在脊椎动物中大多是保守的。GATA1基因被破坏后，小鼠会表现出严重的无血表型。GATA1基因敲低的小鼠易患肿瘤，其程度因敲低水平而异。当GATA1过表达时，某些细胞会面临改变的细胞命运。这些观察结果表明了对GATA1表达水平和时间进行调控的重要性。解读这种调控是理解血细胞定向分化的关键。有许多精彩的综述将GATA1描述为一种转录因子。因此，在本综述中我们将主题聚焦于GATA1基因调控。
