Strange Bryan A, Dolan Raymond J
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK.
Behav Brain Funct. 2007 Jun 13;3:29. doi: 10.1186/1744-9081-3-29.
Detection of salient or motivationally significant stimuli is of adaptive importance. The neurophysiological correlates of this detection have been extensively studied in 'oddball' paradigms. Much theoretical data supports the role of noradrenergic systems in generating oddball responses. We combine psychopharmacology and functional neuroimaging to demonstrate modulation of neuronal responses to oddball nouns by the beta-adrenergic antagonist propranolol. Critically, responses in regions implicated in oddball detection, namely right ventrolateral prefrontal cortex and temporoparietal junction (TPJ), were abolished by propranolol. Thus, oddball responses depend on modulatory adrenergic inputs, mediated via beta-adrenergic receptors.
检测显著或具有动机意义的刺激具有适应性重要性。这种检测的神经生理学相关性已在“oddball”范式中得到广泛研究。许多理论数据支持去甲肾上腺素能系统在产生oddball反应中的作用。我们结合心理药理学和功能神经影像学来证明β-肾上腺素能拮抗剂普萘洛尔对神经元对oddball名词反应的调节作用。至关重要的是，普萘洛尔消除了与oddball检测相关区域的反应，即右侧腹外侧前额叶皮层和颞顶联合区（TPJ）。因此，oddball反应依赖于通过β-肾上腺素能受体介导的调节性肾上腺素能输入。
