比较基因组学：一种对人类DNA进行功能注释的工具。

Comparative genomics: a tool to functionally annotate human DNA.

作者信息

Cheng Jan-Fang, Priest James R, Pennacchio Len A

机构信息

Genomics Division, Lawrence Berkeley National Laboratory, CA, USA.

出版信息

Methods Mol Biol. 2007;366:229-51. doi: 10.1007/978-1-59745-030-0_13.

DOI:10.1007/978-1-59745-030-0_13

PMID:17568128

Abstract

The availability of an increasing number of vertebrate genomes has enabled comparative methods to infer functional sequences based on evolutionary constraint. Although this has proved powerful for gene identification, significant progress has also been made in uncovering gene regulatory sequences such as distant acting transcriptional enhancers. These pursuits have led to the development of a variety of valuable databases and resources that should serve as a routine toolbox for biological discovery.

摘要

越来越多脊椎动物基因组的可得性使得基于进化约束推断功能序列的比较方法成为可能。尽管这已被证明在基因识别方面很强大，但在揭示基因调控序列（如远距离作用的转录增强子）方面也取得了重大进展。这些探索促成了各种有价值的数据库和资源的开发，这些数据库和资源应成为生物学发现的常规工具箱。