Zimmerman Wendy C, Erikson Raymond L
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
Cell Cycle. 2007 Jun 1;6(11):1314-8. doi: 10.4161/cc.6.11.4275. Epub 2007 Jun 11.
Polo-like kinases (Plks) are a highly conserved family of kinases found in flies, yeast and vertebrates. Plks derive their name from homology to the gene product of polo, a protein kinase first identified in Drosophila. Three polo-like kinases have been identified in vertebrates: Plk1, Plk2 and Plk3. Studies on Plk1 have revealed a great deal of information on its multiple functions, however Plk2 and Plk3 functions have not been fully explored. In this perspective we discuss recent work on Plk3 expression, function and localization in the context of previous reports on Plk3 and in terms of its relationship to Plk1.
Polo样激酶（Plks）是在果蝇、酵母和脊椎动物中发现的一个高度保守的激酶家族。Plks得名于与polo基因产物的同源性，polo是一种最初在果蝇中鉴定出的蛋白激酶。在脊椎动物中已鉴定出三种Polo样激酶：Plk1、Plk2和Plk3。对Plk1的研究揭示了其多种功能的大量信息，然而Plk2和Plk3的功能尚未得到充分探索。在这篇综述中，我们结合之前关于Plk3的报道，并根据其与Plk1的关系，讨论了Plk3表达、功能和定位的最新研究进展。
