胆固醇酯转运蛋白I405V多态性与高密度脂蛋白水平升高及心肌梗死风险降低相关：鹿特丹研究
The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study.
作者信息
Isaacs Aaron, Sayed-Tabatabaei Fakhredin A, Hofman Albert, Oostra Ben A, Klungel Olaf H, Maitland-Vander Zee Anke-Hilse, Stricker Bruno H Ch, Witteman Jacqueline C M, van Duijn Cornelia M
机构信息
Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
Eur J Cardiovasc Prev Rehabil. 2007 Jun;14(3):419-21. doi: 10.1097/HJR.0b013e32801101aa.
BACKGROUND AND DESIGN
The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study.
METHODS
Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk.
RESULTS
High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02).
CONCLUSION
This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.
背景与设计
在鹿特丹研究的6421名参与者中，研究了胆固醇酯转运蛋白（CETP）I405V多态性对血脂水平、动脉粥样硬化和心肌梗死（MI）的影响。
方法
采用线性模型研究定量结果；使用Cox模型评估心肌梗死风险。
结果
VV携带者的高密度脂蛋白胆固醇（HDL）升高0.06[95%置信区间（CI）：0.03，0.09]mmol/l。V等位基因还与男性心肌梗死风险降低相关[风险比（95%置信区间）=0.57（0.45，0.73），VV与II相比]（P趋势=0.02）。
结论
本研究为CETP与HDL水平的关联提供了更多证据，并表明CETP是一种增加心肌梗死风险的致动脉粥样硬化蛋白。
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