Tanrikulu Sevda, Ademoglu Evin, Gurdol Figen, Mutlu-Turkoglu Umit, Bilge Ahmet Kaya, Nisanci Yilmaz
Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul, Turkey.
Cell Biochem Funct. 2009 Oct;27(7):452-7. doi: 10.1002/cbf.1593.
In Turkish population, plasma HDL-C levels were found to be lower than in any other country and it is suggested that this is associated with genetic origin. The cholesteryl ester transfer protein (CETP) -629C > A polymorphism is associated with lower plasma CETP concentration, with increased HDL-C level. In the present study, the frequency of -629C > A polymorphism in patients with coronary artery disease (CAD) was investigated and the effect of genotype on HDL-C was evaluated in a Turkish population. For this aim CETP -629C > A polymorphism was studied in angiographically documented CAD patients and healthy controls. There was no statistical significance in the distribution of genotypes between patients and controls. Although A allele carriers with CAD had significantly lower HDL-C levels than controls, plasma lipid levels showed no difference according to the genotypes. Adjustment by a logistic regression model predicting CAD status through HDL-C and including some risk factors as covariate indicated that the HDL-C doesn't have a significant association with CAD risk in CA and AA genotype carriers. Smoking, gender and hypertension were the common predictors for the HDL-C levels in CA and AA carriers. Although HDL-C appeared to be the only significant predictor of CAD in our study groups, the contribution of CETP -629C > A polymorphism to the alterations in HDL-C level appears to be weak to mention a protective effect of this polymorphism for CAD. In conclusion, the findings of the present study indicate that the CETP -629C > A polymorphism is not among the determinants of the coronary artery disease in Turks.
在土耳其人群中，发现血浆高密度脂蛋白胆固醇（HDL-C）水平低于其他任何国家，有人认为这与遗传起源有关。胆固醇酯转运蛋白（CETP）-629C>A多态性与较低的血浆CETP浓度及升高的HDL-C水平相关。在本研究中，调查了冠状动脉疾病（CAD）患者中-629C>A多态性的频率，并在土耳其人群中评估了基因型对HDL-C的影响。为此，在经血管造影证实的CAD患者和健康对照中研究了CETP -629C>A多态性。患者和对照之间基因型分布无统计学意义。虽然CAD的A等位基因携带者的HDL-C水平显著低于对照，但血浆脂质水平根据基因型无差异。通过逻辑回归模型进行调整，该模型通过HDL-C预测CAD状态并将一些危险因素作为协变量纳入，结果表明在CA和AA基因型携带者中，HDL-C与CAD风险无显著关联。吸烟、性别和高血压是CA和AA携带者HDL-C水平的常见预测因素。虽然在我们的研究组中HDL-C似乎是CAD的唯一重要预测因素，但CETP -629C>A多态性对HDL-C水平改变的贡献似乎较弱，不足以提及该多态性对CAD的保护作用。总之，本研究结果表明，CETP -629C>A多态性不是土耳其人冠状动脉疾病的决定因素之一。
