Hollifield Michael, Sinclair-Lian Nityamo, Warner Teddy D, Hammerschlag Richard
Department of Psychiatry and Behavioral Sciences and Family and Geriatric Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
J Nerv Ment Dis. 2007 Jun;195(6):504-13. doi: 10.1097/NMD.0b013e31803044f8.
The purpose of the study was to evaluate the potential efficacy and acceptability of accupuncture for posttraumatic stress disorder (PTSD). People diagnosed with PTSD were randomized to either an empirically developed accupuncture treatment (ACU), a group cognitive-behavioral therapy (CBT), or a wait-list control (WLC). The primary outcome measure was self-reported PTSD symptoms at baseline, end treatment, and 3-month follow-up. Repeated measures MANOVA was used to detect predicted Group X Time effects in both intent-to-treat (ITT) and treatment completion models. Compared with the WLC condition in the ITT model, accupuncture provided large treatment effects for PTSD (F [1, 46] = 12.60; p < 0.01; Cohen's d = 1.29), similar in magnitude to group CBT (F [1, 47] = 12.45; p < 0.01; d = 1.42) (ACU vs. CBT, d = 0.29). Symptom reductions at end treatment were maintained at 3-month follow-up for both interventions. Accupuncture may be an efficacious and acceptable nonexposure treatment option for PTSD. Larger trials with additional controls and methods are warranted to replicate and extend these findings.
本研究的目的是评估针灸治疗创伤后应激障碍（PTSD）的潜在疗效和可接受性。被诊断为创伤后应激障碍的患者被随机分为经验性开发的针灸治疗组（ACU）、团体认知行为治疗组（CBT）或等待名单对照组（WLC）。主要结局指标是在基线、治疗结束时和3个月随访时自我报告的创伤后应激障碍症状。重复测量多变量方差分析用于在意向性治疗（ITT）和治疗完成模型中检测预测的组×时间效应。在ITT模型中，与WLC组相比，针灸对创伤后应激障碍有显著治疗效果（F [1, 46] = 12.60；p < 0.01；Cohen's d = 1.29），其效应大小与团体认知行为治疗相似（F [1, 47] = 12.45；p < 0.01；d = 1.42）（ACU组与CBT组相比，d = 0.29）。两种干预措施在治疗结束时的症状减轻在3个月随访时均得以维持。针灸可能是一种有效且可接受的创伤后应激障碍非暴露治疗选择。有必要进行更大规模的试验，并增加对照组和方法，以重复和扩展这些研究结果。
