Yepiskoposyan Levon, Harutyunyan Ashot
Institute of Man, Yerevan, Armenia.
Eur J Hum Genet. 2007 Sep;15(9):911-6. doi: 10.1038/sj.ejhg.5201869. Epub 2007 Jun 13.
In this review, some principal population genetic features of familial Mediterranean fever (FMF) are considered. These relate to the time and the place of founder mutations' origins, the role of ancient migrations and contacts between populations in the spatial spreading of the disorder, the influence of environmental factors and cultural traditions on the rate of FMF incidence, and possible selective advantage in carriers of FMF causing gene (MEFV) mutations.
在本综述中，我们考虑了家族性地中海热（FMF）的一些主要群体遗传特征。这些特征涉及奠基者突变的起源时间和地点、古代人口迁移以及群体间接触在该疾病空间传播中的作用、环境因素和文化传统对FMF发病率的影响，以及FMF致病基因（MEFV）突变携带者可能存在的选择优势。
