裂殖子表面蛋白2等位基因变异影响巴西疟疾流行地区个体急性疟疾期间的特异性抗体反应。
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area.
作者信息
Sallenave-Sales Selma, Faria Clarissa Perez, Zalis Mariano Gustavo, Daniel-Ribeiro Cláudio Tadeu, Ferreira-da-Cruz Maria de Fátima
机构信息
Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2007 Jun;102(3):421-4. doi: 10.1590/s0074-02762007005000048.
The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.
对自然感染人群中恶性疟原虫寄生虫的抗体反应对于阐明多态性等位基因在疟疾中的作用至关重要。因此，我们通过使用重组裂殖子表面蛋白2（MSP-2）蛋白的酶联免疫吸附测定（ELISA），评估了MSP-2重复和家族双态结构域的抗原多样性对居住在巴西马托格罗索州佩肖托·德阿泽维多的96个人免疫反应的影响。这些个体中的大多数携带FC27型感染。IgG抗体反应主要针对FC27寄生虫，并且与每个MSP-2区域呈现的多态性程度相关。这一发现证明了基因多态性对抗体反应的影响，因此，其对疟疾疫苗效力的重要性。
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