生存素：在胃癌诊断、预后及靶向治疗中的潜在作用
Survivin: potential role in diagnosis, prognosis and targeted therapy of gastric cancer.
作者信息
Wang Ting-Ting, Qian Xiao-Ping, Liu Bao-Rui
机构信息
Department of Oncology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2007 May 28;13(20):2784-90. doi: 10.3748/wjg.v13.i20.2784.
Abstract
Survivin is a protein that is highly expressed in a vast number of malignancies, but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells, thus facilitating the growth of these cells. In the case of gastric cancer, survivin is over-expressed in tumor cells and plays a role in the carcinogenesis process. Several studies on gastric cancer have indicated that there is a relationship between survivin expression and the ultimate behavior of the carcinoma. Since the expression pattern of survivin is selective to cancer cells, it has been described as an "ideal target" for cancer therapy. Currently, several pre-clinical and clinical trials are on-going to investigate the effects of interfering with survivin function in cancer cells as a biologic therapy. Survivin is a potentially significant protein in the diagnosis, prognosis and treatment of gastric tumors.
摘要
生存素是一种在大量恶性肿瘤中高表达，但在正常组织中低表达的蛋白质。它在癌细胞中作为细胞死亡的抑制剂发挥作用，从而促进这些细胞的生长。在胃癌中，生存素在肿瘤细胞中过度表达，并在致癌过程中发挥作用。几项关于胃癌的研究表明，生存素表达与癌的最终行为之间存在关联。由于生存素的表达模式对癌细胞具有选择性，它被描述为癌症治疗的“理想靶点”。目前，正在进行几项临床前和临床试验，以研究干扰癌细胞中生存素功能作为一种生物疗法的效果。生存素在胃肿瘤的诊断、预后和治疗中是一种潜在的重要蛋白质。
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