鸟氨酸脱羧酶在胃癌前病变和癌性病变中的表达。
Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions.
作者信息
Miao Xin-Pu, Li Jian-Sheng, Li Hui-Yan, Zeng Shi-Ping, Zhao Ye, Zeng Jiang-Zheng
机构信息
Department of Gastroenterology, West China Hospital of Sichuan University, 17 Renmin Avenue, Chengdu 610041, Sichuan Province, China.
出版信息
World J Gastroenterol. 2007 May 28;13(20):2867-71. doi: 10.3748/wjg.v13.i20.2867.
AIM
To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions.
METHODS
We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG, n=32), chronic atrophic gastritis [CAG, n=43; 15 with and 28 without intestinal metaplasia (IM)], gastric dysplasia (DYS, n=11) and gastric cancer (GC, n=48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy.
METHODS
The positive rate of ODC expression was 34.4%, 42.9%, 73.3%, 81.8% and 91.7% in cases with CSG, CAG without IM, CAG with IM, DYS and GC, respectively (P<0.01), The positive rate of ODC expression increased in the order of CSG < CAG (without IM) < CAG (with IM) < DYS and finally, GC. In addition, ODC positive immunostaining rate was lower in well-differentiated GC than in poorly-differentiated GC (P<0.05).
CONCLUSION
The expression of ODC is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. This finding indicates that ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions.
目的
研究鸟氨酸脱羧酶（ODC）在胃癌前病变及癌性胃病变中的表达情况。
方法
我们采用免疫组织化学染色法，研究了慢性浅表性胃炎（CSG，n = 32）、慢性萎缩性胃炎[CAG，n = 43；其中15例伴有肠化生（IM），28例不伴有肠化生]、胃发育异常（DYS，n = 11）及胃癌（GC，n = 48）患者胃黏膜中ODC的表达。所有134例胃黏膜活检标本均通过胃镜采集。
结果
ODC表达的阳性率在CSG、不伴有IM的CAG、伴有IM的CAG、DYS及GC病例中分别为34.4%、42.9%、73.3%、81.8%及91.7%（P < 0.01），ODC表达的阳性率按照CSG < CAG（不伴有IM）< CAG（伴有IM）< DYS，最终到GC的顺序升高。此外，高分化GC中ODC阳性免疫染色率低于低分化GC（P < 0.05）。
结论
ODC的表达与胃黏膜恶性程度及胃病变的发展呈正相关。这一发现表明ODC可作为癌前病变筛查及诊断中的良好生物标志物。
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