Miao Xin-Pu, Li Jian-Sheng, Li Hui-Yan, Zeng Shi-Ping, Zhao Ye, Zeng Jiang-Zheng
Department of Gastroenterology, West China Hospital of Sichuan University, 17 Renmin Avenue, Chengdu 610041, Sichuan Province, China.
World J Gastroenterol. 2007 May 28;13(20):2867-71. doi: 10.3748/wjg.v13.i20.2867.
To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions.
We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG, n=32), chronic atrophic gastritis [CAG, n=43; 15 with and 28 without intestinal metaplasia (IM)], gastric dysplasia (DYS, n=11) and gastric cancer (GC, n=48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy.
The positive rate of ODC expression was 34.4%, 42.9%, 73.3%, 81.8% and 91.7% in cases with CSG, CAG without IM, CAG with IM, DYS and GC, respectively (P<0.01), The positive rate of ODC expression increased in the order of CSG < CAG (without IM) < CAG (with IM) < DYS and finally, GC. In addition, ODC positive immunostaining rate was lower in well-differentiated GC than in poorly-differentiated GC (P<0.05).
The expression of ODC is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. This finding indicates that ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions.
研究鸟氨酸脱羧酶（ODC）在胃癌前病变及癌性胃病变中的表达情况。
我们采用免疫组织化学染色法，研究了慢性浅表性胃炎（CSG，n = 32）、慢性萎缩性胃炎[CAG，n = 43；其中15例伴有肠化生（IM），28例不伴有肠化生]、胃发育异常（DYS，n = 11）及胃癌（GC，n = 48）患者胃黏膜中ODC的表达。所有134例胃黏膜活检标本均通过胃镜采集。
ODC表达的阳性率在CSG、不伴有IM的CAG、伴有IM的CAG、DYS及GC病例中分别为34.4%、42.9%、73.3%、81.8%及91.7%（P < 0.01），ODC表达的阳性率按照CSG < CAG（不伴有IM）< CAG（伴有IM）< DYS，最终到GC的顺序升高。此外，高分化GC中ODC阳性免疫染色率低于低分化GC（P < 0.05）。
ODC的表达与胃黏膜恶性程度及胃病变的发展呈正相关。这一发现表明ODC可作为癌前病变筛查及诊断中的良好生物标志物。
