Tian Xiao-hui, Xue Wu-jun, Li Da-qing, Tian Pu-xun, Ding Xiao-ming, Pan Xiao-ming, Hou Jun
Center of Renal Transplantation, the First Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Zhonghua Nan Ke Xue. 2007 May;13(5):431-4.
To study the impacts of kidney transplantation on erectile function and analyse its contributing factors.
In order to evaluate the severity of erectile dysfunction (ED), a total of 250 married male kidney transplant recipients (KTR) with functioning graft were assessed with the International Index of Erectile Function (IIEF) questionnaire. Data of clinical characteristics, medical and sexual history and laboratory examination were collected. Univariate and multivariate logistic regression analyses were carried out to determine which have independent impacts on erectile function.
The investigation was accomplished in 84.8% of the KTRs. There was no significant difference in ED incidence before and after renal transplantation (53.8% vs. 44.3%, P > 0.05). According to the IIEF score, erectile function improved in 43.9% of the KTRs, remained unchanged in 42.9%, and deteriorated in 13.2%, as compared with pre-transplantation. Logistic regression analysis showed that significant and independent influencing factors in erectile function were age, hemoglobin level, presence of DM and/or peripheral neuropathy and iterative transplantations, and their relative risks were 3.01, 2.01, 3.15, 3.89 and 2.67, respectively.
ED is highly prevalent among KTRs and its pathogenesis is multifactorial. Age, presence of DM and/or peripheral neuropathy, hemoglobin level and iterative transplantations were chief contributing factors in erectile function.
研究肾移植对勃起功能的影响并分析其影响因素。
为评估勃起功能障碍（ED）的严重程度，采用国际勃起功能指数（IIEF）问卷对250例移植肾功能良好的已婚男性肾移植受者（KTR）进行评估。收集临床特征、病史及性生活史和实验室检查数据。进行单因素和多因素逻辑回归分析以确定哪些因素对勃起功能有独立影响。
84.8%的KTR完成了调查。肾移植前后ED发生率无显著差异（53.8%对44.3%，P>0.05）。根据IIEF评分，与移植前相比，43.9%的KTR勃起功能改善，42.9%保持不变，13.2%恶化。逻辑回归分析显示，对勃起功能有显著且独立影响的因素为年龄、血红蛋白水平、糖尿病和/或周围神经病变的存在以及再次移植，其相对风险分别为3.01、2.01、3.15、3.89和2.67。
ED在KTR中非常普遍，其发病机制是多因素的。年龄、糖尿病和/或周围神经病变的存在、血红蛋白水平和再次移植是勃起功能的主要影响因素。
