胆碱能囊泡：独立于细胞质乙酰胆碱进行排空和再填充的能力。
Cholinergic vesicles: ability to empty and refill independently of cytoplasmic acetylcholine.
作者信息
Carrol P T, Nelson S H
机构信息
Department of Pharmacology and Toxicology, University of Rhode Island, Kingston, RI 02881, USA.
出版信息
Science. 1978 Jan 6;199(4324):85-6. doi: 10.1126/science.199.4324.85.
Incubation of minced mouse-forebrain tissues in lithium Krebs solution reduces the acetylcholine content of the vesicular fraction 70 percent without altering that of the cytoplasmic fraction. Depleted vesicular-bound acetylcholine can be restored with newly synthesized acetylcholine (formed from extracellular choline) independently of the cytoplasmic pool. Depletion of vesicular-bound acetylcholine does not facilitate the movement of preformed extracellular acetylcholine into vesicles.
将小鼠前脑组织碎片置于锂盐 Krebs 溶液中孵育，可使囊泡部分的乙酰胆碱含量降低 70%，而细胞质部分的乙酰胆碱含量则无变化。耗尽的囊泡结合型乙酰胆碱可通过新合成的乙酰胆碱（由细胞外胆碱形成）得以恢复，且与细胞质库无关。囊泡结合型乙酰胆碱的耗尽并不促进预先形成的细胞外乙酰胆碱向囊泡内的移动。
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