Topcuoglu Pervin, Akcaglayan Soydan Ender, Ekiz Fuat, Ayyildiz Erol, Dalva Klara, Ozcan Muhit, Arslan Onder, Arat Mutlu, Ilhan Osman
Ankara University, Faculty of Medicine, Department of Hematology, Hemapheresis and Blood Bank, Cebeci Kampüsü, 06590 Dikimevi, Ankara, Turkey.
Transfus Apher Sci. 2007 Jun;36(3):275-80. doi: 10.1016/j.transci.2007.03.007. Epub 2007 Jun 13.
Transplant physicians are generally using the recipient's actual body weight (ABW) for the calculation of the content of CD34+ cells in the harvest material in hematopoietic stem cell transplantation (HSCT). As a reference center performing both the stem cell collection and HSCTs, we aimed to evaluate whether there were any differences for neutrophil recovery by calculating the CD34+ cell content in the graft according to actual, ideal (IBW) or adjusted IBW (AIBW) of the recipients in both autologous (n=148) and allogeneic stem cell collection setting (n=234). We observed a negative correlation between the neutrophil recovery and the cell doses infused as to each of these BWs in the allo-HSCT group, but not in the auto-HSCT group. This negative correlation was stronger for IBW and AIBW rather than for ABW in allo-HSCT group. In addition, calculations for both IBW and AIBW in autologous and allogeneic transplants revealed a significant difference in comparison to ABW for different cut-off values of infused CD34+ cells. Consequently, we suggested that both IBW and AIBW based calculations of CD34+ cells infused are better predictors of neutrophil recovery in comparison to ABW in allo-HSCT. We were not able to show this impact in autologous transplants.
在造血干细胞移植（HSCT）中，移植医生通常使用受者的实际体重（ABW）来计算采集材料中CD34+细胞的含量。作为一个同时进行干细胞采集和HSCT的参考中心，我们旨在评估在自体（n = 148）和异基因干细胞采集组（n = 234）中，根据受者的实际体重、理想体重（IBW）或调整后的理想体重（AIBW）计算移植物中CD34+细胞含量时，中性粒细胞恢复是否存在差异。在异基因HSCT组中，我们观察到中性粒细胞恢复与根据这些体重中的每一种所输注的细胞剂量之间呈负相关，但在自体HSCT组中未观察到这种相关性。在异基因HSCT组中，这种负相关性在IBW和AIBW时比在ABW时更强。此外，在自体和异基因移植中，针对IBW和AIBW的计算显示，与ABW相比，对于不同的输注CD34+细胞临界值存在显著差异。因此，我们认为，与ABW相比，在异基因HSCT中，基于IBW和AIBW计算输注的CD34+细胞是中性粒细胞恢复的更好预测指标。在自体移植中，我们未能显示出这种影响。
