Sergeev A S
Genetika. 1991 Jul;27(7):1254-63.
Conditional probability approach in estimation of recurrence risks in sibships of different parental phenotypic matings with the different set of affected and normal siblings is considered. The formulae are presented for calculation of recurrence risks in cases of equal and different susceptibility of two sexes under different ways of sampling of family data: direct selection of offsprings through the parents; indirect selection of offsprings through affected siblings--the probands, under different ascertainment probability--from pi = 1.0 ("exhaustive selection") up to pi----0 ("single selection"); for the case of different susceptibility of the two sexes a possibility of the differences in the ascertainment probabilities of men (pi m) and of women (pi w) is allowed, unlike "independent ascertainment model", which requires the constancy of pi. The case of multiple incompatible subforms is considered for estimation of the recurrence risks of the specified subforms. The methods of the risks estimation proposed are free of genetic models being universal both for classical mendelian traits (with the constant risks) and for multifactorial ones (with variable risks).
本文考虑了条件概率方法，用于估计不同亲本表型交配的同胞对中复发风险，这些同胞对具有不同组的患病和正常兄弟姐妹。给出了在不同家庭数据抽样方式下，计算两性易感性相同和不同情况下复发风险的公式：通过父母直接选择后代；通过患病兄弟姐妹（先证者）间接选择后代，在不同的确定概率下，从π = 1.0（“详尽选择”）到π----0（“单次选择”）；对于两性易感性不同的情况，允许男性（πm）和女性（πw）的确定概率存在差异，这与“独立确定模型”不同，后者要求π恒定。考虑了多个不相容子形式的情况，用于估计指定子形式的复发风险。所提出的风险估计方法不受遗传模型限制，对经典孟德尔性状（风险恒定）和多因素性状（风险可变）均具有通用性。
