Wu Qingyu, Parry Gordon
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Front Biosci. 2007 Sep 1;12:5052-9. doi: 10.2741/2447.
Hepsin is a membrane serine protease expressed in several human tissues including the liver, kidney, prostate, and thyroid. The physiological function of hepsin remains unknown. In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). Recently, hepsin has been identified as one of the most up-regulated genes in prostate cancer. The hepsin up-regulation appears to correlate with the disease progression. In a mouse model of prostate cancer, hepsin overexpression promotes cancer progression and metastasis. In culture, anti-hepsin antibodies inhibited the invasion of human prostate cancer cells. This review will outline the molecular biology and biochemistry of hepsin and highlight recent data of hepsin in prostate cancer.
海普辛是一种膜丝氨酸蛋白酶，在包括肝脏、肾脏、前列腺和甲状腺在内的多种人体组织中表达。海普辛的生理功能尚不清楚。体外研究表明，海普辛可激活凝血因子VII、XII和IX、尿激酶原（pro-uPA）以及肝细胞生长因子原（pro-HGF）。最近，海普辛已被确定为前列腺癌中上调最为明显的基因之一。海普辛的上调似乎与疾病进展相关。在前列腺癌小鼠模型中，海普辛的过表达促进癌症进展和转移。在培养实验中，抗海普辛抗体抑制了人前列腺癌细胞的侵袭。本综述将概述海普辛的分子生物学和生物化学，并重点介绍海普辛在前列腺癌中的最新研究数据。
