Peitl Barna, Szilvássy Zoltán
Department of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032, Debrecen, Hungary.
Metabolism. 2007 Jul;56(7):863-4. doi: 10.1016/j.metabol.2007.03.004.
We studied the role of cholecystokinin in meal-induced insulin sensitization in rats. Experiments were done with fed or fasted male Wistar rats. Whole-body insulin sensitivity was determined by the rapid insulin sensitivity test in either group. The fed animals were more sensitive to the hypoglycemic effect of insulin than those in the fasted group. Single intravenous doses of proglumide, a cholecystokinin-1 receptor antagonist, decreased insulin sensitivity in fed animals in a dose-dependent manner, whereas it was without effect in the fasted state. We conclude that prandial insulin sensitization strongly depends on pathways regulated by cholecystokinin.
我们研究了胆囊收缩素在大鼠进食诱导的胰岛素敏感性中的作用。实验在喂食或禁食的雄性Wistar大鼠身上进行。通过快速胰岛素敏感性试验测定两组大鼠的全身胰岛素敏感性。喂食的动物比禁食组的动物对胰岛素的降血糖作用更敏感。单次静脉注射胆囊收缩素-1受体拮抗剂丙谷胺，以剂量依赖的方式降低了喂食动物的胰岛素敏感性，而在禁食状态下则没有效果。我们得出结论，餐后胰岛素敏感性强烈依赖于由胆囊收缩素调节的途径。
