Prasad H Keshava, Kaushal Varsha, Mehta Paulette
Department of Hematology/Oncology, Central Arkansas Veterans Healthcare Service, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Am J Hematol. 2007 Sep;82(9):855-7. doi: 10.1002/ajh.20949.
Thalidomide is being increasingly used in hematology and oncology. Its use is associated with neuropathy, sedation, edema, fatigue, constipation, and deep venous thrombosis. Cytopenias are unusual, but there are case reports. However, there are no reports of isolated thrombocytopenia. We describe here a case of prolonged isolated thrombocytopenia most likely caused by thalidomide. The patient's in platelet count decreased promptly after an increase in the dose and improved after discontinuation of the drug. The relevant literature is reviewed.
沙利度胺在血液学和肿瘤学中的应用日益广泛。其使用与神经病变、镇静作用、水肿、疲劳、便秘及深静脉血栓形成有关。血细胞减少并不常见，但有病例报告。然而，尚无孤立性血小板减少症的报告。我们在此描述一例很可能由沙利度胺引起的持续性孤立性血小板减少症病例。患者在增加剂量后血小板计数迅速下降，停药后有所改善。并对相关文献进行了综述。
