Blasi Paolo, Giovagnoli Stefano, Schoubben Aurélie, Ricci Maurizio, Rossi Carlo
Department of Chemistry and Technology of Drugs, School of Pharmacy, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Adv Drug Deliv Rev. 2007 Jul 10;59(6):454-77. doi: 10.1016/j.addr.2007.04.011. Epub 2007 May 22.
The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes. The state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices. The available literature on solid lipid nanoparticles and related carriers for brain drug targeting is revised as well. The potential advantages of the use of solid lipid nanoparticles over polymeric nanoparticles are accounted on the bases of a lower cytotoxicity, higher drug loading capacity, and best production scalability. Solid lipid nanoparticles physicochemical characteristics are also particularly regarded in order to address the critical issues related to the development of suitable brain targeting formulations. A critical consideration on the potential application of such technology as related to the current status of brain drug development is also given.
本综述讨论了固体脂质纳米粒用于脑靶向给药的潜在用途。通过强调将该技术转移至固体脂质基质，介绍了专门设计用于脑靶向的表面活性剂包衣聚（烷基氰基丙烯酸酯）纳米粒的最新进展。同时也对固体脂质纳米粒及相关脑靶向给药载体的现有文献进行了修订。基于较低的细胞毒性、较高的载药能力和良好的生产可扩展性，阐述了使用固体脂质纳米粒相对于聚合物纳米粒的潜在优势。还特别关注了固体脂质纳米粒的物理化学特性，以解决与开发合适的脑靶向制剂相关的关键问题。此外，还对该技术与当前脑药物开发现状相关的潜在应用进行了批判性思考。
