Malone M
Department of Histopathology, Hospitals for Sick Children, London, UK.
Histopathology. 1991 Aug;19(2):105-19. doi: 10.1111/j.1365-2559.1991.tb00001.x.
The histiocytoses of childhood include Langerhans' cell histiocytosis, haemophagocytic syndrome (familial and reactive), sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease), juvenile xanthogranuloma and malignant histiocytosis. These disorders show wide variation in their clinical presentation, prognosis and genetic implications. All are characterized by localized or generalized proliferation of histiocytes, but they differ in their morphology, histochemical and immunochemical staining patterns and electronmicroscopical features. On the basis of a comprehensive clinical history and critical interpretation of morphology and immunocytochemistry using an appropriately selected panel of antibodies, a diagnosis can be reached in the majority of cases.
儿童组织细胞增多症包括朗格汉斯细胞组织细胞增多症、噬血细胞综合征（家族性和反应性）、伴有巨大淋巴结病的窦性组织细胞增多症（罗萨伊-多夫曼病）、幼年性黄色肉芽肿和恶性组织细胞增多症。这些疾病在临床表现、预后和遗传学意义方面差异很大。所有这些疾病的特征都是组织细胞的局部或全身性增殖，但它们在形态学、组织化学和免疫化学染色模式以及电子显微镜特征方面有所不同。根据全面的临床病史以及使用适当选择的抗体组合对形态学和免疫细胞化学进行的批判性解读，大多数病例都可以做出诊断。
