Ko Hyoung-Gon, Lee Sung Joong, Son Hyeon, Kaang Bong-Kiun
National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak-gu, Seoul, Korea.
Mol Pain. 2007 Jun 15;3:16. doi: 10.1186/1744-8069-3-16.
It is well known that antidepressants increase neurogenesis in the dentate gyrus of the hippocampus. The increase of neurogenesis might contribute to the behavioral effects of antidepressants. However, the mechanism by which antidepressants increase hippocampal neurogenesis is largely unknown. It has been recently reported that astroglia induce the neurogenesis of the hippocampal neural progenitor cells (NPCs). Therefore, we hypothesized that antidepressants may act on astrocytes, and this in turn induces neurogenesis of NPCs.
To examine this hypothesis, we used two co-culture systems, i.e., a contact-independent Banker culture and a contact-dependent overlay co-culture. In both of these systems, in comparison with naïve astrocytes, antidepressant-treated astrocytes did not further increase the proliferation of NPCs.
These results suggest that astrocytes increase the proliferation of hippocampal NPCs, however, this may not be directly involved in the antidepressant-induced proliferation of NPCs.
众所周知，抗抑郁药可增加海马齿状回中的神经发生。神经发生的增加可能有助于抗抑郁药的行为效应。然而，抗抑郁药增加海马神经发生的机制在很大程度上尚不清楚。最近有报道称，星形胶质细胞可诱导海马神经祖细胞（NPCs）的神经发生。因此，我们推测抗抑郁药可能作用于星形胶质细胞，进而诱导NPCs的神经发生。
为检验这一假设，我们使用了两种共培养系统，即非接触式的Banker培养和接触式的覆盖共培养。在这两种系统中，与未处理的星形胶质细胞相比，经抗抑郁药处理的星形胶质细胞并未进一步增加NPCs的增殖。
这些结果表明，星形胶质细胞可增加海马NPCs的增殖，然而，这可能并非直接参与抗抑郁药诱导的NPCs增殖。
