Bilgic Ayse, Ozdemir F Nurhan, Bayraktar Nilufer, Karakus Sema, Sasak Gulsah, Arat Zubeyde, Sezer Siren, Haberal Mehmet
Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.
Am J Nephrol. 2007;27(4):366-72. doi: 10.1159/000103911. Epub 2007 Jun 13.
BACKGROUND/AIMS: Arteriovenous fistulae (AVF) thrombosis is a common cause of morbidity in hemodialysis (HD) patients. Increased soluble endothelial protein C receptor (sEPCR) levels have been associated with increased risk of venous thrombosis. We aimed to investigate the possible effects of sEPCR levels on the development of AVF thrombosis in adult HD patients.
60 HD patients and 22 healthy controls were included. Patients were followed for 18 months and were divided into two groups according to AVF thrombosis development: group 1 (with thrombosis) and group 2 (without thrombosis). Also, patients classified into tertiles according to plasma sEPCR levels: lowest, intermediate, and highest. Groups were analyzed for any relationship between sEPCR levels and development of AVF thrombosis.
Mean plasma sEPCR levels were significantly higher in HD patients than they were in controls. Group 1 patients had significantly higher sEPCR levels compared with group 2 patients. Patients' groups were similar regarding other possible risk factors for AVF thromboses. The rate of AVF thrombosis development was significantly higher in the highest sEPCR tertile.
This is the first study to analyze sEPCR levels in HD patients. Our findings demonstrate a relationship between plasma sEPCR levels and development of AVF thromboses.
背景/目的：动静脉内瘘（AVF）血栓形成是血液透析（HD）患者发病的常见原因。可溶性内皮蛋白C受体（sEPCR）水平升高与静脉血栓形成风险增加有关。我们旨在研究sEPCR水平对成年HD患者AVF血栓形成发展的可能影响。
纳入60例HD患者和22例健康对照。对患者进行18个月的随访，并根据AVF血栓形成情况分为两组：第1组（有血栓形成）和第2组（无血栓形成）。此外，根据血浆sEPCR水平将患者分为三分位数：最低、中间和最高。分析各组sEPCR水平与AVF血栓形成发展之间的关系。
HD患者的平均血浆sEPCR水平显著高于对照组。与第2组患者相比，第1组患者的sEPCR水平显著更高。患者组在AVF血栓形成的其他可能危险因素方面相似。sEPCR最高三分位数组中AVF血栓形成的发生率显著更高。
这是第一项分析HD患者sEPCR水平的研究。我们的研究结果表明血浆sEPCR水平与AVF血栓形成发展之间存在关联。
