谷胱甘肽S-转移酶M1和T1基因多态性与加勒比地区非洲裔人群前列腺癌风险
GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent.
作者信息
Mallick Stéphane, Romana Marc, Blanchet Pascal, Multigner Luc
机构信息
Department of Urology, University Hospital, Pointe à Pitre, Guadeloupe.
出版信息
Urology. 2007 Jun;69(6):1165-9. doi: 10.1016/j.urology.2007.02.039.
OBJECTIVES
To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe.
METHODS
We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (CIs). Genotypes were determined by multiplex polymerase chain reaction.
RESULTS
The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9).
CONCLUSIONS
A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean population of African descent.
目的
研究谷胱甘肽S-转移酶基因多态性GSTM1和/或GSTT1是否与瓜德罗普岛非洲裔加勒比人群的前列腺癌风险相关。
方法
我们进行了一项基于医院的病例对照研究，纳入134例前列腺癌患者和134例年龄匹配的无癌对照对象。使用标准问卷收集流行病学数据。采用逻辑回归估计比值比（OR）并计算置信区间（CI）。通过多重聚合酶链反应确定基因型。
结果
患者中GSTM1阳性基因型的频率为81%，对照对象中为73%，校正后的OR为1.4（95%CI 0.7至2.5）。患者中GSTT1阳性基因型的频率为78%，对照对象中为63%，校正后的OR为2.6（95%CI 1.4至4.9）。
结论
功能性GSTT1基因多态性可能与非洲裔加勒比人群的前列腺癌易感性相关。
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