Wang Ying, He Jing, Ma Tian-Jiao, Lei Wei, Li Feng, Shen Han, Shen Zhen-Ya
Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China.
Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China.; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
J Cancer. 2016 Jul 26;7(12):1680-1693. doi: 10.7150/jca.15494. eCollection 2016.
gene plays an important role in detoxification and clearance of reactive oxygen species(ROS). A null variant in this gene has been demonstrated to confer cancer susceptibility. Although many studies have demonstrated the association between null polymorphism and urinary system cancer susceptibility, several publications reported opposite conclusions. For better understanding the effects of this polymorphism on the risk of urinary system cancer, a updated meta-analysis was performed with a total of 26,666 cases and 37,210 controls extracted from 117 studies, by following the latest meta-analysis guidelines (PRISMA). The results suggested that the null genotype was significantly associated with an increased risk of urinary system cancer (OR=1.13, 95%CI=1.05-1.22). Furthermore, stratified analyses by the type of cancer, ethnicity, source of control and quality score presented a significantly increased risk associated with null genotype in bladder and prostate cancer subgroup, Caucasians and Indians subgroup, population-based(PB) subgroup, medium quality and low quality subgroup. Overall, our meta-analysis suggested that null genotype is a potential cancer susceptibility variant. Well-designed and large-cohort studies are needed to confirm the association between null genotype and urinary system cancer risk.
基因在活性氧（ROS）的解毒和清除过程中发挥着重要作用。该基因的一个无效变异已被证明会导致癌症易感性。尽管许多研究已经证明了无效多态性与泌尿系统癌症易感性之间的关联，但也有一些出版物报道了相反的结论。为了更好地理解这种多态性对泌尿系统癌症风险的影响，我们按照最新的荟萃分析指南（PRISMA）进行了一项更新的荟萃分析，共纳入了从117项研究中提取的26,666例病例和37,210例对照。结果表明，无效基因型与泌尿系统癌症风险增加显著相关（OR = 1.13，95%CI = 1.05 - 1.22）。此外，按癌症类型、种族、对照来源和质量评分进行的分层分析显示，在膀胱癌和前列腺癌亚组、白种人和印度人亚组、基于人群（PB）的亚组、中等质量和低质量亚组中，无效基因型与风险显著增加相关。总体而言，我们的荟萃分析表明，无效基因型是一种潜在的癌症易感性变异。需要设计良好的大型队列研究来证实无效基因型与泌尿系统癌症风险之间的关联。
