Fujioka K, Sugi K, Isago T, Flynn J T, Traber L D, Herndon D N, Traber D L
Department of Anesthesiology, University of Texas Medical Branch, Galveston 77550.
J Appl Physiol (1985). 1991 Oct;71(4):1376-81. doi: 10.1152/jappl.1991.71.4.1376.
We studied the cardiopulmonary response to endotoxin (lipopolysaccharide, LPS) in sheep with and without the administration of a thromboxane synthase inhibitor, OKY-046. The animals were instrumented for crystalographic dimension analysis of the left ventricle (LV) and for measurement of LV, aortic, left atrial, and pulmonary arterial pressures and cardiac index, as well as lung lymph flow. They received 1.0 micrograms/kg of Escherichia coli LPS with (n = 8) and without (n = 8) OKY-046 (10 mg/kg bolus, then 10 micrograms.kg-1.min-1). OKY-046 prevented the increase of pulmonary arterial pressure and the decrease of cardiac index that occurred during the early phase of endotoxemia. Between 8 and 12 h after LPS, cardiac index increased from 6.8 +/- 0.7 to 8.9 +/- 0.51.min-1.m-2. Concomitantly, the end-systolic pressure-diameter relationship (ESPDR, sensitive myocardial contractility index) significantly decreased from 14.7 +/- 0.6 to 7.7 +/- 0.7. Other indexes of the LV contractility (+dP/dtmax) were also reduced. OKY-046 prevented the decreases of ESPDR and +dP/dtmax. OKY-046 also attenuated the increased lung lymph flow changes seen with LPS.
我们研究了在给予和不给予血栓素合酶抑制剂OKY - 046的情况下，绵羊对内毒素（脂多糖，LPS）的心肺反应。对动物进行仪器植入，用于左心室（LV）的晶体学尺寸分析以及测量LV、主动脉、左心房和肺动脉压力、心脏指数以及肺淋巴流量。它们接受了1.0微克/千克的大肠杆菌LPS，其中8只给予OKY - 046（10毫克/千克推注，然后10微克·千克⁻¹·分钟⁻¹），8只未给予。OKY - 046可预防内毒素血症早期出现的肺动脉压力升高和心脏指数降低。在给予LPS后8至12小时，心脏指数从6.8±0.7增加至8.9±0.5升·分钟⁻¹·米⁻²。与此同时，收缩末期压力 - 直径关系（ESPDR，敏感的心肌收缩性指数）从14.7±0.6显著降至7.7±0.7。LV收缩性的其他指标（+dP/dtmax）也降低。OKY - 046可预防ESPDR和 +dP/dtmax的降低。OKY - 046还减轻了LPS引起的肺淋巴流量增加的变化。
