Joglekar N, Joshi S, Kakde M, Fang G, Cianciola M, Reynolds S, Mehendale S
National AIDS Research Institute, Indian Council of Medical Research (ICMR), India.
AIDS Care. 2007 Jul;19(6):817-21. doi: 10.1080/09540120601133576.
Acceptability of PRO2000 Gel, a candidate vaginal microbicide, among participants of its Phase I safety study in Pune, India is reported here. Forty-two eligible women were enrolled in a study requiring twice daily intra-vaginal product use for 14 consecutive days between menses. Acceptability was assessed at study exit through structured questionnaires among 41 participants who completed the product use, and five focus group discussions involving 31 study participants. The participants generally liked the product (40/41, 97.2%), especially its colour (40, 97.2%) and consistency (35, 85.3%). Thirty-four participants reported sexual intercourse within one hour of product use, at least once during the study period and sexual pleasure was reported to be better or unaffected among (30, 88.2%) participants. Nearly 70% did not like its smell and mentioned preference for a product that would be unnoticeable to the male partner. Participating women were concerned about privacy in usage and storage of the product. Acceptability of PRO2000 vaginal gel was good, but its smell will have to be improved. Counselling to address women's concerns about privacy and storage will be crucial. Women's preference for unnoticeable product indicates their empowerment and willingness to accept female-controlled options for HIV prevention.
本文报道了候选阴道杀菌剂PRO2000凝胶在印度浦那进行的I期安全性研究参与者中的可接受性。42名符合条件的女性参与了一项研究，该研究要求在两次月经期间连续14天每天两次阴道内使用该产品。在研究结束时，通过结构化问卷对41名完成产品使用的参与者进行了可接受性评估，并对31名研究参与者进行了五次焦点小组讨论。参与者总体上喜欢该产品（40/41，97.2%），尤其喜欢其颜色（40人，97.2%）和质地（35人，85.3%）。34名参与者报告在使用产品后一小时内发生性行为，在研究期间至少有一次，88.2%（30人）的参与者报告性快感更好或未受影响。近70%的人不喜欢它的气味，并表示更喜欢男性伴侣不易察觉的产品。参与研究的女性担心产品使用和储存过程中的隐私问题。PRO2000阴道凝胶的可接受性良好，但其气味有待改善。解决女性对隐私和储存问题的咨询至关重要。女性对不易察觉产品的偏好表明她们有自主权，并愿意接受女性主导的艾滋病毒预防方案。
