Kaijzel Eric L, van der Pluijm Gabri, Löwik Clemens W G M
Departments of Endocrinology and Metabolic Diseases and Urology, Leiden University Medical Center, Leiden, the Netherlands.
Clin Cancer Res. 2007 Jun 15;13(12):3490-7. doi: 10.1158/1078-0432.CCR-07-0402.
Different optical-based imaging models were used to investigate tumor progression and metastasis with particular emphasis on metastasis to bone and bone marrow. We describe how optical imaging can be used to follow important processes in tumor development and treatment response, including angiogenesis, apoptosis, and proteolysis. Finally, we discuss the translation of one optical imaging modality, near-IR fluorescence, from animal validation studies to applications in the clinic related to cancer management.
不同的基于光学的成像模型被用于研究肿瘤进展和转移，尤其侧重于骨和骨髓转移。我们描述了光学成像如何用于跟踪肿瘤发展和治疗反应中的重要过程，包括血管生成、细胞凋亡和蛋白水解。最后，我们讨论了一种光学成像模式——近红外荧光成像，从动物验证研究到与癌症管理相关的临床应用的转化。
