Department of Urology, Leiden University Medical Center, J3-100, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Future Oncol. 2012 Apr;8(4):415-30. doi: 10.2217/fon.12.33.
Bone metastasis is a complex process that ultimately leads to devastating metastatic bone disease. It is therefore of key interest to unravel the mechanisms underlying the multistep process of skeletal metastasis and cancer-induced bone disease, and to develop better treatment and management of patients with this devastating disease. Fortunately, novel technologies are rapidly emerging that allow real-time imaging of molecules, pathogenic processes, drug delivery and drug response in preclinical in vivo models. The outcome of these experimental studies will facilitate clinical cancer research by improving the detection of cancer cell invasion, metastasis and therapy response.
骨转移是一个复杂的过程，最终导致破坏性的转移性骨病。因此，解开骨骼转移和癌症引起的骨病的多步骤过程的机制，并开发更好的治疗和管理这种破坏性疾病的患者是至关重要的。幸运的是，新技术正在迅速涌现，允许在临床前体内模型中实时成像分子、发病过程、药物输送和药物反应。这些实验研究的结果将通过提高对癌细胞侵袭、转移和治疗反应的检测，促进临床癌症研究。
