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一名对贝拉普罗斯和沙格雷酯无反应的特发性肺动脉高压患者使用西地那非后有显著改善。

Marked improvement with sildenafil in a patient with idiopathic pulmonary arterial hypertension unresponsive to beraprost and sarpogrelate.

作者信息

Kawano Hiroaki, Sengyoku Hideyori, Satoh Osami, Urabe Shigetoshi, Koide Yuji, Yano Katsusuke

机构信息

Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University.

出版信息

Intern Med. 2007;46(12):893-8. doi: 10.2169/internalmedicine.46.1848. Epub 2007 Jun 15.

DOI:10.2169/internalmedicine.46.1848
PMID:17575385
Abstract

We report a 16-year-old man with severe heart failure due to idiopathic pulmonary arterial hypertension (IPAH). The patient was initially treated with a combination of beraprost, a prostacyclin analog, and sarpogrelate, a serotonin receptor inhibitor. However, he was unresponsive to the treatment. We then changed the treatment to sildenafil, and his condition dramatically improved. Sildenafil has an immediate pulmonary vasodilator effect in patients already receiving vasodilators for IPAH.

摘要

我们报告了一名16岁因特发性肺动脉高压（IPAH）导致严重心力衰竭的男性患者。该患者最初接受了前列环素类似物贝前列素和5-羟色胺受体抑制剂沙格雷酯联合治疗。然而，他对该治疗无反应。随后我们将治疗改为西地那非，他的病情显著改善。西地那非对已接受IPAH血管扩张剂治疗的患者具有即时肺血管扩张作用。

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Marked improvement with sildenafil in a patient with idiopathic pulmonary arterial hypertension unresponsive to beraprost and sarpogrelate.一名对贝拉普罗斯和沙格雷酯无反应的特发性肺动脉高压患者使用西地那非后有显著改善。
Intern Med. 2007;46(12):893-8. doi: 10.2169/internalmedicine.46.1848. Epub 2007 Jun 15.
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Marked improvement with sildenafil in a patient with primary pulmonary hypertension unresponsive to epoprostenol.一名对依前列醇无反应的原发性肺动脉高压患者使用西地那非后有显著改善。
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[Treatment with sildenafil, bosentan, or both in children and young people with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome].[西地那非、波生坦或两者联合治疗儿童及青年特发性肺动脉高压和艾森曼格综合征]
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Bosentan and sildenafil: should the combination therapy be a valid alternative in childhood to prostacyclin infusion?波生坦与西地那非：联合治疗能否成为儿童期替代前列环素输注的有效选择？
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[The combined use of sildenafil with epoprostenol in a patient with primary pulmonary hypertension].[西地那非与依前列醇联合用于一名原发性肺动脉高压患者的治疗]
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引用本文的文献

1
Sildenafil for the treatment of pulmonary hypertension in pediatric patients.西地那非用于治疗儿科患者的肺动脉高压。
Pediatr Cardiol. 2009 Oct;30(7):871-82. doi: 10.1007/s00246-009-9523-1. Epub 2009 Aug 25.