一名对贝拉普罗斯和沙格雷酯无反应的特发性肺动脉高压患者使用西地那非后有显著改善。
Marked improvement with sildenafil in a patient with idiopathic pulmonary arterial hypertension unresponsive to beraprost and sarpogrelate.
作者信息
Kawano Hiroaki, Sengyoku Hideyori, Satoh Osami, Urabe Shigetoshi, Koide Yuji, Yano Katsusuke
机构信息
Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University.
出版信息
Intern Med. 2007;46(12):893-8. doi: 10.2169/internalmedicine.46.1848. Epub 2007 Jun 15.
We report a 16-year-old man with severe heart failure due to idiopathic pulmonary arterial hypertension (IPAH). The patient was initially treated with a combination of beraprost, a prostacyclin analog, and sarpogrelate, a serotonin receptor inhibitor. However, he was unresponsive to the treatment. We then changed the treatment to sildenafil, and his condition dramatically improved. Sildenafil has an immediate pulmonary vasodilator effect in patients already receiving vasodilators for IPAH.
我们报告了一名16岁因特发性肺动脉高压（IPAH）导致严重心力衰竭的男性患者。该患者最初接受了前列环素类似物贝前列素和5-羟色胺受体抑制剂沙格雷酯联合治疗。然而，他对该治疗无反应。随后我们将治疗改为西地那非，他的病情显著改善。西地那非对已接受IPAH血管扩张剂治疗的患者具有即时肺血管扩张作用。
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