Chen Lin, Wang Xinliang, Lu Tao, Hou Taiping
Key Laboratory of Bio-Resource and Eco-environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Pest Manag Sci. 2007 Sep;63(9):928-34. doi: 10.1002/ps.1399.
Starting from the chemical structure of the botanical aphicides 1,5-diphenyl-1-pentanone and 1,5-diphenyl-2-penten-1-one, extracted from Stellera chamaejasme L., the authors designed and synthesized a series of novel compounds following the concept of bioisosterism. Their structures were established on the basis of (1)H NMR and GC-MS spectra, and the insecticidal activities of the compounds were evaluated against Aphis gossypii Glover. The results demonstrated that the substitution of a heterocycle for the phenyl ring was favourable. Thus, further modification of compound 2n, containing a furan ring, which showed excellent activity (LC(50) = 0.85 g L(-1)), is of some promise.
从瑞香狼毒中提取的植物源杀蚜剂1,5 - 二苯基 - 1 - 戊酮和1,5 - 二苯基 - 2 - 戊烯 - 1 - 酮的化学结构出发，作者依据生物电子等排体概念设计并合成了一系列新型化合物。通过¹H NMR和GC - MS光谱确定了它们的结构，并针对棉蚜对这些化合物的杀虫活性进行了评估。结果表明，用杂环取代苯环是有利的。因此，对含有呋喃环且表现出优异活性（LC₅₀ = 0.85 g L⁻¹）的化合物2n进行进一步修饰具有一定前景。
