Deulofeut Richard, Dudell Golde, Sola Augusto
Emory University School of Medicine, Division of Neonatal-Perinatal Medicine, Atlanta, Georgia, USA.
Acta Paediatr. 2007 Jul;96(7):990-4. doi: 10.1111/j.1651-2227.2007.00365.x.
To examine gender-specific differences in response to the O(2) saturation (SpO(2)) targets aimed at avoiding hyperoxia in very low birth weight infants (VLBW).
Analysis of a prospectively collected database of all infants </=1250 g in two perinatal centres. A change was instituted in January 2003 with the objective of avoiding hyperoxia with target SpO(2) at 85-93% (period II). Prior to this, SpO(2) high alarms were set at 100% and low alarms at 92% (period I; from January 2000 to December 2002).
Of the 497 infants that met enrolment criteria, 297 (60%) were born during period I and 140 (47%) of them were male. During period II, 200 infants were born and 101 (50%) were male. Analysis by gender showed that the rate of retinopathy of prematurity, bronchopulmonary dysplasia and length of stay is significantly better for female infants than males on period II compared to period I. Neither gender experienced increased short-term neurological morbidity in response to lower SpO(2) targets.
There is a significant gender-specific difference favouring females in the beneficial effects produced by avoiding high SpO(2) and hyperoxia, with no difference in the distribution of any potential short-term detrimental effects.
研究极低出生体重儿（VLBW）为避免高氧血症而设定的氧饱和度（SpO₂）目标在性别上的差异。
对两个围产期中心前瞻性收集的所有体重≤1250克婴儿的数据库进行分析。2003年1月实施了一项改变，目标是将SpO₂目标设定在85% - 93%以避免高氧血症（第二阶段）。在此之前，SpO₂高报警设定为100%，低报警设定为92%（第一阶段；2000年1月至2002年12月）。
符合纳入标准的497名婴儿中，297名（60%）在第一阶段出生，其中140名（47%）为男性。在第二阶段，有200名婴儿出生，101名（50%）为男性。按性别分析表明，与第一阶段相比，第二阶段女婴的早产儿视网膜病变、支气管肺发育不良发生率及住院时间明显优于男婴。在较低的SpO₂目标下，两性均未出现短期神经功能障碍发生率增加的情况。
在避免高SpO₂和高氧血症产生的有益效果方面，存在显著的性别差异，女性更具优势，且在任何潜在短期有害影响的分布上无差异。
