Nakamura Shigeki, Yanagihara Katsunori, Seki Masafumi, Izumikawa Koichi, Higashiyama Yasuhito, Miyazaki Yoshitsugu, Hirakata Yoichi, Mizuta Yohei, Kohno Shigeru
Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan.
Scand J Infect Dis. 2007;39(6-7):521-4. doi: 10.1080/00365540701199816.
We wished to assess the clinical differences between beta-lactamase-negative, ampicillin-sensitive and beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae pneumonia. The medical records of 118 patients with H. influenzae pneumonia admitted between March 1998 and March 2003 to Nagasaki University Hospital and affiliated institutions were reviewed. In line with CLSI (Clinical and Laboratory Standards Institute) criteria, we classified H. influenzae according to sensitivity to ampicillin as follows: S (sensitive), minimum inhibitory concentration (MIC) =1; I (intermediate sensitivity), MIC =2; R (resistant), MIC =4. We defined the R strains as the BLNAR group and the S and I strains as the non-BLNAR group. We measured the patient's background, Pneumonia Severity Index (PSI), drug sensitivity of H. influenzae, and evaluation of antibiotic choices. There were no significant clinical differences between the beta-lactamase-negative, ampicillin-susceptible and the beta-lactamase-negative, ampicillin-resistant groups. However, BLNAR pneumonia was more prominent in the younger than the older patients. This study should provide useful information for understanding the clinical characteristics of BLNAR pneumonia.
我们希望评估β-内酰胺酶阴性、氨苄西林敏感和β-内酰胺酶阴性、氨苄西林耐药的流感嗜血杆菌肺炎之间的临床差异。回顾了1998年3月至2003年3月期间入住长崎大学医院及附属机构的118例流感嗜血杆菌肺炎患者的病历。根据CLSI（临床和实验室标准协会）标准，我们将流感嗜血杆菌按照对氨苄西林的敏感性分类如下：S（敏感），最低抑菌浓度（MIC）=1；I（中度敏感），MIC =2；R（耐药），MIC =4。我们将R菌株定义为BLNAR组，将S和I菌株定义为非BLNAR组。我们测量了患者的背景、肺炎严重程度指数（PSI）、流感嗜血杆菌的药敏情况以及对抗生素选择的评估。β-内酰胺酶阴性、氨苄西林敏感组和β-内酰胺酶阴性、氨苄西林耐药组之间在临床方面没有显著差异。然而，BLNAR肺炎在年轻患者中比老年患者中更为突出。本研究应为理解BLNAR肺炎的临床特征提供有用信息。
