边缘区B淋巴细胞发育过程中NF-κB1/p50与Notch2之间的协同作用。

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

作者信息

Moran Stewart T, Cariappa Annaiah, Liu Haoyuan, Muir Beth, Sgroi Dennis, Boboila Cristian, Pillai Shiv

机构信息

Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA.

出版信息

J Immunol. 2007 Jul 1;179(1):195-200. doi: 10.4049/jimmunol.179.1.195.

DOI:10.4049/jimmunol.179.1.195

PMID:17579038

Abstract

NF-kappaB1 and Notch2 are both required for the development of marginal zone (MZ) B cells. Analysis of B lymphocyte development in mice that are doubly heterozygous at the Notch2 and NF-kappaB1 loci revealed synergism between Notch2 and NF-kappaB1 during MZ B cell development. Two known transcriptional targets of the Notch pathway, Hes-5 and Deltex-1, were found to be preferentially expressed in MZ B cells and regulated by NF-kappaB1. These studies provide in vivo evidence for a genetic interaction between the Notch and NF-kappaB pathways.

摘要

核因子κB1（NF-kappaB1）和Notch2都是边缘区（MZ）B细胞发育所必需的。对在Notch2和NF-kappaB1基因座处双杂合的小鼠的B淋巴细胞发育进行分析，结果显示在MZ B细胞发育过程中Notch2和NF-kappaB1之间存在协同作用。Notch信号通路的两个已知转录靶标Hes-5和Deltex-1，被发现优先在MZ B细胞中表达并受NF-kappaB1调控。这些研究为Notch和NF-kappaB信号通路之间的遗传相互作用提供了体内证据。