Yakubovich N, Fung M A, Thompson D M
Division of Endocrinology, University of British Columbia, Vancouver, Canada.
Transplant Proc. 2007 Jun;39(5):1599-603. doi: 10.1016/j.transproceed.2007.01.074.
Transmission of cytomegalovirus (CMV) is uncommon in patients transplanted with CMV-mismatched pancreatic islets, and CMV-seropositive recipients rarely experience reactivation of the virus or reinfection from a CMV-positive graft. This study describes three cases of CMV infection following islet transplantation for type 1 diabetes despite prophylaxis with valganciclovir. Further studies are needed to evaluate risk factors for CMV transmission and reactivation in this patient population.
巨细胞病毒（CMV）在接受CMV不匹配胰岛移植的患者中传播并不常见，CMV血清学阳性的受者很少经历病毒再激活或从CMV阳性移植物中再次感染。本研究描述了3例1型糖尿病患者在接受胰岛移植后发生CMV感染的病例，尽管使用了缬更昔洛韦进行预防。需要进一步研究以评估该患者群体中CMV传播和再激活的危险因素。
