Kubal C, Cacciola R, Riley P, Ready A
Department of Renal Transplantation, the University Hospital Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands, United Kingdom.
Transplant Proc. 2007 Jun;39(5):1676-8. doi: 10.1016/j.transproceed.2007.03.018.
A 49-year-old man underwent living donor renal transplantation in November 2005. The transplant renal artery was anastomosed to the right internal iliac artery with an end-to-end anastomosis. The patient achieved immediate graft function and the allograft was normally perfused. Seven weeks later, renal allograft function deteriorated with a serum creatinine level increased to 244 micromol/L. An ultrasound scan revealed adequate perfusion to the kidney and the absence of hydronephrosis. A transplant biopsy revealed Banff IB rejection, which was treated with high-dose prednisolone. Following biopsy, the patient's renal function rapidly deteriorated with a serum creatinine level increased to 627 micromol/L, requiring hemodialysis. A computed tomography (CT) angiogram demonstrated a 6-cm diameter pseudoaneurysm arising from the internal iliac artery with absence of kidney perfusion. The aneurysm was accessed percutaneously with a 4-F catheter and 1000 U of human thrombin injected, resulting in partial thrombosis of the pseudoaneurysm. A balloon expandable covered metal stent was then placed across the site of the transplant renal artery anastomosis, resulting in successful occlusion of the aneurysm. Intrarenal blood flow was established by dilating 2 intrarenal branches with 3-mm diameter balloons. The serum creatinine level started to decrease within 24 hours of the procedure and renal function improved rapidly to a level achieved immediately after transplantation. Three months later the patient had a well-functioning allograft with a serum creatinine level of 176 micromol/L, follow-up CT scan demonstrated good perfusion of the transplanted kidney with no further change in the pseudoaneurysm. At 12 months follow-up the patient remains with a well-functioning allograft.
一名49岁男性于2005年11月接受了活体供肾肾移植手术。移植肾动脉与右髂内动脉进行了端端吻合。患者移植肾立即恢复功能,移植肾灌注正常。七周后,移植肾功能恶化,血清肌酐水平升至244微摩尔/升。超声检查显示肾脏灌注充足,无肾积水。移植肾活检显示为Banff IB级排斥反应,给予大剂量泼尼松龙治疗。活检后,患者肾功能迅速恶化,血清肌酐水平升至627微摩尔/升,需要进行血液透析。计算机断层扫描(CT)血管造影显示髂内动脉出现一个直径6厘米的假性动脉瘤,肾脏无灌注。经皮用4F导管进入动脉瘤,注入1000单位人凝血酶,导致假性动脉瘤部分血栓形成。然后在移植肾动脉吻合部位放置一个球囊可扩张带膜金属支架,成功闭塞动脉瘤。通过用直径3毫米的球囊扩张2个肾内分支建立肾内血流。术后24小时内血清肌酐水平开始下降,肾功能迅速改善至移植后立即达到的水平。三个月后,患者移植肾功能良好,血清肌酐水平为176微摩尔/升,随访CT扫描显示移植肾灌注良好,假性动脉瘤无进一步变化。在12个月的随访中,患者移植肾功能仍然良好。