黄素辅酶的多样作用——自然界最多才多艺的演员。
The diverse roles of flavin coenzymes--nature's most versatile thespians.
作者信息
Mansoorabadi Steven O, Thibodeaux Christopher J, Liu Hung-wen
机构信息
Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, USA.
出版信息
J Org Chem. 2007 Aug 17;72(17):6329-42. doi: 10.1021/jo0703092. Epub 2007 Jun 20.
Abstract
Flavin coenzymes play a variety of roles in biological systems. This Perspective highlights the chemical versatility of flavins by reviewing research on five flavoenzymes that have been studied in our laboratory. Each of the enzymes discussed in this review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase reductase (E3), CDP-4-aceto-3,6-dideoxygalactose synthase (YerE), UDP-galactopyranose mutase (UGM), and type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2)] utilizes flavin in a distinct role. In particular, the catalytic mechanisms of two of these enzymes, UGM and IDI-2, may involve novel flavin chemistry.
摘要
黄素辅酶在生物系统中发挥着多种作用。本综述通过回顾我们实验室对五种黄素酶的研究，突出了黄素的化学多样性。本综述中讨论的每种酶[酰基辅酶A脱氢酶（ACD）、CDP-6-脱氧-L-苏糖-D-甘油-4-己酮糖-3-脱水酶还原酶（E3）、CDP-4-乙酰基-3,6-二脱氧半乳糖合酶（YerE）、UDP-吡喃半乳糖变位酶（UGM）和II型异戊烯基二磷酸：二甲基烯丙基二磷酸异构酶（IDI-2）]都以独特的方式利用黄素。特别是，其中两种酶UGM和IDI-2的催化机制可能涉及新颖的黄素化学。
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