Puccio V F, Soliani M, Corea D, Puncuh F, Massone M L, Nahum L, Pisano F, Castellani R, Cornaglia-Ferraris P
Unità di Terapia Intensiva Neonatale e Pediatrica, Istituto G. Gaslini, Genova.
Minerva Pediatr. 1991 Oct;43(10):637-44.
Fifty eight premature infants, all needing intensive care and mechanical ventilation, were randomly allocated to two groups. Intravenous immunoglobulins (IVIG, 500 mg/kg Sandoglobulin) were administered to Group 1 while Group 2 received saline as placebo. IgG subclass serum levels were evaluated in both groups on admission, after two hours from the end of IVIG or saline infusion and from day 3 to 7 from birth. IgG subclasses were also measured in 10 healthy term neonates during the first day of life. Results show that after 2 hours from the end of IVIG administration all IgG subclasses reach levels comparable to term neonates. Comparing IgG values between treated and untreated preterm neonates it was observed that on day 3 only IgG1 and IgG3 subclasses were significantly higher in Group 1 than in Group 2. At day 5 no differences were observed between the two groups. IgG2 subclass rose reaching a significant difference between the two groups ad day 5 and 7. Our data show that IVIG single dose (500 mg/kg) administration doesn't produce a constant elevation in all IgG subclasses during the first week of life in the critically ill preterm infant.
58名均需重症监护和机械通气的早产儿被随机分为两组。第一组给予静脉注射免疫球蛋白（IVIG，500mg/kg桑球蛋白），而第二组接受生理盐水作为安慰剂。在入院时、IVIG或生理盐水输注结束后两小时以及出生后第3至7天对两组的IgG亚类血清水平进行评估。还在10名健康足月儿出生第一天测量了IgG亚类。结果显示，IVIG给药结束后两小时，所有IgG亚类的水平均达到与足月儿相当的水平。比较治疗组和未治疗组早产儿的IgG值，发现第3天时只有第一组的IgG1和IgG3亚类显著高于第二组。第5天时两组之间未观察到差异。IgG2亚类上升，在第5天和第7天时两组之间出现显著差异。我们的数据表明，在危重症早产儿出生后的第一周内，单次剂量（500mg/kg）的IVIG给药并不会使所有IgG亚类持续升高。
