Barron S, Foss J A, Riley E P
Department of Psychology, San Diego State University, CA 92182-0350.
Neurotoxicol Teratol. 1991 Sep-Oct;13(5):503-6. doi: 10.1016/0892-0362(91)90057-4.
Umbilical cord length has been considered a reliable indicator of fetal movement. In this study, the effect of prenatal cocaine exposure on umbilical cord length was examined in rats. Pregnant rats were intubated with either 0 or 60 mg/kg cocaine hydrochloride daily from gestation day (GD) 14-21. Fetuses were removed via Caesarean section on GD 21 and umbilical cord length, placental weight and fetal body weight were measured. Fetuses exposed to cocaine in utero had significantly shorter umbilical cords than intubated controls, although there were no differences in placental or fetal body weights. These data suggest that prenatal cocaine exposure suppresses fetal movement, which could contribute to some of the long-term effects observed in cocaine-exposed offspring.
脐带长度一直被视为胎儿活动的可靠指标。在本研究中，检测了产前可卡因暴露对大鼠脐带长度的影响。从妊娠第14天至21天，每天给怀孕大鼠插管注入0或60mg/kg盐酸可卡因。在妊娠第21天通过剖腹产取出胎儿，并测量脐带长度、胎盘重量和胎儿体重。尽管胎盘或胎儿体重没有差异，但子宫内暴露于可卡因的胎儿脐带明显短于插管对照组。这些数据表明，产前可卡因暴露会抑制胎儿活动，这可能是可卡因暴露后代中观察到的一些长期影响的原因之一。
