Smith Fiona E, Langley Philip, van Leeuwen Peter, Hailer Birgit, Trahms Lutz, Steinhoff Uwe, Bourke John P, Murray Alan
Medical Physics Department, Freeman Hospital Unit, Newcastle upon Tyne, UK.
Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:20-2.
Automated techniques were developed for the measurement of cardiac repolarisation using magnetocardiography.
This was achieved by collaboration with the Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany and the Grönemeyer Institute of Microtherapy, Bochum, Germany, to obtain recordings of magnetocardiograms (MCGs) in cardiac patients and healthy subjects. Manual and automated ventricular repolarisation measurements from MCGs were evaluated to determine the clinical relevance of these measurements compared with electrocardiograms (ECGs).
Results showed that MCG and ECG T-wave shapes differed and that manual repolarisation measurement was significantly influenced by T-wave amplitude. Automatic measurements of repolarisation in both MCGs and ECGs differed between techniques. The effects of filtering on the waveforms showed that filtering in some MCG research systems could significantly influence the results, with 20 ms differences common. In addition, MCGs were better able to identify differences in the distribution of cardiac magnetic field strength during repolarisation and depolarisation between normal subjects and cardiac patients. Differences were also determined in ventricular repolarisation between MCGs and ECGs, which cannot be explained by channel/lead numbers or amplitude effects alone.
The techniques developed are essential, because of the many extra MCG channels to analyse, and will encourage the use of MCG facilities.
开发了利用心磁图测量心脏复极的自动化技术。
这是通过与德国柏林的物理技术联邦研究所（PTB）以及德国波鸿的格罗内迈尔微疗法研究所合作实现的，以获取心脏病患者和健康受试者的心磁图（MCG）记录。对MCG的手动和自动心室复极测量进行评估，以确定与心电图（ECG）相比这些测量的临床相关性。
结果表明，MCG和ECG的T波形状不同，并且手动复极测量受T波振幅的显著影响。MCG和ECG中复极的自动测量在技术之间存在差异。滤波对波形的影响表明，一些MCG研究系统中的滤波会显著影响结果，常见的差异为20毫秒。此外，MCG能够更好地识别正常受试者和心脏病患者在复极和去极化期间心脏磁场强度分布的差异。还确定了MCG和ECG之间心室复极的差异，这不能仅通过通道/导联数量或振幅效应来解释。
所开发的技术至关重要，因为有许多额外的MCG通道需要分析，并且将鼓励心磁图设备的使用。
