Vergara Pasquale, Picardi Giuseppe, Nigro Gerardo, Scafuro Francesco, de Chiara Annabella, Calabrò Raffaele, Vergara Giuseppe
Cardiology Department, Second University of Naples, Naples, Italy.
Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:104-6.
Atrial fibrillation (AF) is the most frequent cause of hospitalization for arrhythmias. The aim of our study was to evaluate the prevalence of thyroid dysfunction in patients with paroxysmal AF without any cardiomyopathy.
Two hundred sixty eight patients (164 women and 104 men, mean age 64.9+/-16.9 years) affected by paroxysmal AF entered the present study. Patients underwent routine laboratory examinations with estimation of thyroid hormones levels, standard electrocardiogram (ECG) and transthoracic echocardiography.
Thyroid stimulating hormone (TSH) levels were low (<0.3 mU/L) in 168 patients (62.7%) and high (>5 mU/L) in 39 patients (14.9%); 76 patients (28.4%) had high free triiodothyronine (FT3) levels (>4.3 pg/ml) and 91 patients (34.3%) had high free thyroxine (FT4) levels (>1.7 ng/dl); 60 patients (22.4%) had low FT3 levels (<2 pg/ml) and 24 patients (9%) had low FT4 levels (<0.9 ng/dl). Overall, 76.2% of patients with hyperthyroidism were women. Hyperthyroidism was considered subclinical in 68 (40.5%) patients with low SH concentrations.
Thyroid dysfunctions have a high prevalence in AF patients and hyperthyroidism is the most common disorder. Hyperthyroidism in AF patients more often occurs in women than in men. Any minimal but persistent modification of circulating thyroid hormone levels can favor episodes of AF; it can be useful to thoroughly assess thyroid function in all patients suffering from AF.
心房颤动（AF）是心律失常住院治疗最常见的原因。我们研究的目的是评估无任何心肌病的阵发性AF患者甲状腺功能障碍的患病率。
268例阵发性AF患者（164例女性和104例男性，平均年龄64.9±16.9岁）纳入本研究。患者接受常规实验室检查，包括甲状腺激素水平测定、标准心电图（ECG）和经胸超声心动图检查。
168例患者（62.7％）促甲状腺激素（TSH）水平低（<0.3 mU/L），39例患者（14.9％）促甲状腺激素水平高（>5 mU/L）；76例患者（28.4％）游离三碘甲状腺原氨酸（FT3）水平高（>4.3 pg/ml），91例患者（34.3％）游离甲状腺素（FT4）水平高（>1.7 ng/dl）；60例患者（22.4％）FT3水平低（<2 pg/ml），24例患者（9％）FT4水平低（<0.9 ng/dl）。总体而言，76.2％的甲状腺功能亢进患者为女性。68例（40.5％）SH浓度低的患者被认为是亚临床甲状腺功能亢进。
AF患者甲状腺功能障碍患病率高，甲状腺功能亢进是最常见的疾病。AF患者的甲状腺功能亢进在女性中比在男性中更常见。循环甲状腺激素水平的任何微小但持续的改变都可能引发AF发作；全面评估所有AF患者的甲状腺功能可能会有所帮助。
