Cho Meyoung, Choi Chang Soo, Seo Geom Seog, Kim Tae Hyeon, Choi Suck Chei, Yun Ki Jung, Kim Haak Cheoul
Digestive Desease Reserch Institute, Wonkwang University School of Medicine, Iksan, Korea.
Korean J Hepatol. 2007 Jun;13(2):234-8.
Common metastatic sites of hepatocellular carcinoma include lung, peritoneum, adrenal gland and bone, but rarely, skin can be metastatic sites. Although hepatocellular carcinoma is the third commonest malignancy in Korea, cutaneous metastasis from hepatocellular carcinoma was rarely reported. Cutaneous metastasis from malignant neoplasm of the internal organ occur at the variable stage and the growth pattern of cutaneous lesions is nonspecific and various, so the differential diagnosis of skin lesions must be considered to other malignant condition. We report a case of cutaneous metastasis from recurrent hepatocellular carcinoma that was confirmed by skin biopsy with immunohistochemical stain.
肝细胞癌常见的转移部位包括肺、腹膜、肾上腺和骨骼,但皮肤作为转移部位较为罕见。虽然肝细胞癌是韩国第三大常见恶性肿瘤,但肝细胞癌皮肤转移的报道却很少。内脏恶性肿瘤的皮肤转移发生在不同阶段,皮肤病变的生长模式是非特异性且多样的,因此必须考虑将皮肤病变与其他恶性疾病进行鉴别诊断。我们报告一例复发性肝细胞癌皮肤转移病例,经皮肤活检及免疫组化染色得以确诊。