Royer Michael C, Rush Walter L, Lupton George P
Department of Pathology and Area Laboratory Services, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Am J Dermatopathol. 2008 Feb;30(1):77-80. doi: 10.1097/DAD.0b013e31815ea24f.
The authors report a case of hepatocellular carcinoma (HCC) diagnosed by evaluation of a cutaneous metastasis in a patient without a prior diagnosis of HCC. Subsequent evaluation confirmed the presence of additional widespread metastatic disease. The medical literature is reviewed with regards to cutaneous metastasis, including precocious metastasis, of HCC. The pathologic evaluation of HCC is reviewed, including a discussion of the immunohistochemical profile of this malignancy and the utility of hepatocyte paraffin 1, CD10, and polyclonal carcinoembryonic antigen (pCEA) immunohistochemical stains.
作者报告了一例肝细胞癌（HCC）病例，该病例是通过对一名既往未诊断出HCC的患者的皮肤转移灶进行评估而确诊的。后续评估证实存在其他广泛转移的疾病。本文回顾了有关HCC皮肤转移（包括早熟转移）的医学文献。还回顾了HCC的病理评估，包括对这种恶性肿瘤的免疫组织化学特征以及肝细胞石蜡1、CD10和多克隆癌胚抗原（pCEA）免疫组织化学染色的效用的讨论。
