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[副流感嗜血杆菌——心内膜炎的罕见病因]

[Haemophilus parainfluenzae--a rare cause of endocarditis].

作者信息

Ledina Dragan, Karanović Jakica, Ivić Ivo, Karanović Nenad, Ledina Dubravka

机构信息

Odjel za zarazne bolesti, Klinicka bolnica Split, Split, Hrvatska.

出版信息

Acta Med Croatica. 2007 Apr;61(2):219-22.

Abstract

Haemophilus parainfluenzae endocarditis is a rare acute or subacute disease. It is usually associated with dental and surgical procedures in the oral cavity. In a 23-year-old athlete admitted to Department of Infectious Diseases, Split University Hospital, the diagnosis of infective endocarditis was established based on Duke's criteria. The patient was not exposed to risky medical procedures nor he had a predisposing heart disease. The course of illness was characterized by peripheral embolizations (splinter hemorrhages and petechiae) and vegetation on the dorsal mitral valve. After seven days of incubation, blood cultures revealed Haemophilus parainfluenzae. The patient was treated intravenously with amoxicillin-clavulanic acid plus gentamicin for four weeks. Peroral therapy was continued with amoxicillin-clavulanic acid alone for two weeks. By the end of treatment, heart ultrasound showed disappearance of endocardial vegetation. Echocardiographic and clinical examinations performed at 3, 6 and 12 months of therapy showed no pathological aberrations.

摘要

副流感嗜血杆菌性心内膜炎是一种罕见的急性或亚急性疾病。它通常与口腔的牙科和外科手术有关。在一名入住斯普利特大学医院传染病科的23岁运动员中,根据杜克标准确诊为感染性心内膜炎。该患者未接受过有风险的医疗程序,也没有易患心脏病。病程的特征是外周栓塞(裂片出血和瘀点)以及二尖瓣背侧有赘生物。经过7天的培养,血培养显示为副流感嗜血杆菌。患者接受了静脉注射阿莫西林 - 克拉维酸加庆大霉素治疗四周。之后继续口服阿莫西林 - 克拉维酸单独治疗两周。治疗结束时,心脏超声显示心内膜赘生物消失。在治疗的3个月、6个月和12个月进行的超声心动图和临床检查均未发现病理异常。

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