Filaretov A A, Podvigina T T, Bogdanova T S
Laboratory of Experimental Endocrinology, I.P. Pavlov Institute of Physiology, Academy of Sciences, USSR, Leningrad.
Neurosci Behav Physiol. 1991 Sep-Oct;21(5):448-52. doi: 10.1007/BF01200280.
The relationship of the magnitude of the response of the hypophyseoadrenocortical system (HACS) to the strength of the stimulus in the presence of isolated or repeated stressor influences was determined in experiments on awake rats. Electrical stimulation of 0.1-0.9 mA of the skin of the paws for 3 min served as the stimulus. The reaction of HACS was judged on the basis of the determination of blood corticosteroids. Changes take place in the physiological characteristics of the system 30 mins after the termination of the stressor activation of the HACS. These changes do not depend on the strength of the initial stressor, and consist of a decrease in the threshold of excitability and a reduction in the maximum of the reaction to stressors of greater strength. The reaction to repeated stimulation at small strengths of the initial stressor proved to be larger or equal to the response of the system to the initial stimulation. At greater strengths of the stressor the reaction to repeated stimulation is significantly less than to the initial stimulation.
在清醒大鼠实验中，确定了在存在孤立或重复应激源影响的情况下，垂体肾上腺皮质系统（HACS）反应的大小与刺激强度之间的关系。以0.1 - 0.9 mA的电流对爪部皮肤进行3分钟的电刺激作为刺激。根据血液中皮质类固醇的测定来判断HACS的反应。在HACS的应激源激活终止30分钟后，该系统的生理特征会发生变化。这些变化不依赖于初始应激源的强度，包括兴奋性阈值降低以及对更强应激源反应的最大值减小。事实证明，在初始应激源强度较小时，对重复刺激的反应大于或等于系统对初始刺激的反应。在应激源强度较大时，对重复刺激的反应明显小于对初始刺激的反应。
