Mateo I, Llorca J, Infante J, Rodríguez-Rodríguez E, Fernández-Viadero C, Peña N, Berciano J, Combarros O
Neurology Service, 'Marqués de Valdecilla' University Hospital, University of Cantabria, Santander, Spain.
Acta Neurol Scand. 2007 Jul;116(1):56-8. doi: 10.1111/j.1600-0404.2006.00775.x.
As vascular endothelial growth factor (VEGF) determines important neurotrophic and neuroprotective actions, we postulated serum VEGF levels could be abnormally low in patients with Alzheimer's disease (AD).
We measured serum VEGF levels (VEGF(165) isoform by ELISA) in 51 patients with AD by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorder Association criteria and compared with 66 age- and gender-matched non-demented controls. Patients with AD were stratified into levels of dementia severity by the Clinical Dementia Rating scale. Serum VEGF levels were stratified into upper (>309 pg/ml), middle (207-309 pg/ml), and lower (<207 pg/ml) tertiles. VEGF (-2,578) (rs 699,947) and VEGF (-634) (rs 2,010,963) polymorphisms were genotyped in patients with AD and controls.
The mean concentration of VEGF in the serum of patients with AD (215.9 pg/ml, SD 101.5) was significantly lower than that of the controls (308.6 pg/ml, SD 223.9, P = 0.004), and decreased serum VEGF levels were associated with AD in a dose-dependent manner, the lower tertile of serum VEGF levels being associated with a fivefold increased risk for AD when compared with the upper tertile. There was no significant correlation between serum VEGF levels and age, sex, APOE alleles, AD dementia severity nor VEGF gene polymorphisms.
Decrease in serum VEGF levels could contribute to the neurodegenerative process in AD.
由于血管内皮生长因子（VEGF）决定着重要的神经营养和神经保护作用，我们推测阿尔茨海默病（AD）患者血清VEGF水平可能异常降低。
我们按照美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会标准，对51例AD患者测定血清VEGF水平（采用ELISA法检测VEGF(165)异构体），并与66例年龄和性别匹配的非痴呆对照者进行比较。根据临床痴呆评定量表将AD患者分为痴呆严重程度不同的等级。血清VEGF水平分为上三分位数（>309 pg/ml）、中三分位数（207 - 309 pg/ml）和下三分位数（<207 pg/ml）。对AD患者和对照者进行VEGF (-2,578)（rs 699,947）和VEGF (-634)（rs 2,010,963）基因多态性基因分型。
AD患者血清中VEGF的平均浓度（215.9 pg/ml，标准差101.5）显著低于对照组（308.6 pg/ml，标准差223.9，P = 0.004），血清VEGF水平降低与AD呈剂量依赖性相关，血清VEGF水平下三分位数者患AD的风险是上三分位数者的5倍。血清VEGF水平与年龄、性别、APOE等位基因、AD痴呆严重程度及VEGF基因多态性之间无显著相关性。
血清VEGF水平降低可能促成AD的神经退行性病变过程。
