The Cardiovascular Institute, Minato-ku, Tokyo 106-0032, Japan.
Circ J. 2007;71 Suppl A:A40-4. doi: 10.1253/circj.71.a40.
Atrial fibrillation (AF), one of the most common arrhythmias, has grown to be an important medical problem in societies with an increasing number of aged people, because AF is strongly associated with the occurrence of severe thromboembolism. Although the processes underlying AF-associated thrombosis have long been believed to be mainly dependent upon the decreased blood flow in the left atrium induced by AF, revisiting the well known Virchow's triad from the basic approach has disclosed that this is too simplistic. Here, the role of 3 important components, abnormalities in the blood flow, blood coagulability, and the endocardial function of the atria, in thrombus formation in the fibrillating atria are discussed. Unraveling the molecular basis of thrombus formation in the atrium could open a new era of a wide variety of management of stroke prevention for AF patients.
心房颤动（AF）是最常见的心律失常之一，随着老年人口的增加，它已成为一个重要的医学问题，因为 AF 与严重血栓栓塞的发生密切相关。尽管长期以来人们一直认为，与 AF 相关的血栓形成过程主要依赖于 AF 引起的左心房血流减少，但从基础方法重新审视著名的 Virchow 三联征表明，这过于简单化。在这里，讨论了在颤动的心房中血栓形成的 3 个重要组成部分，即血流、血液凝固性和心房心内膜功能的异常的作用。揭示心房内血栓形成的分子基础可能开创 AF 患者预防中风的各种管理的新时代。
