Kelishadi Roya, Ardalan Gelayol, Adeli Khosrow, Motaghian Molouk, Majdzadeh Reza, Mahmood-Arabi Minoo Sadat, Delavari Alireza, Riazi Mohammad Mehdi, Namazi Roshanak, Ramezani Mohammad Arash
Preventive Pediatric Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ann Nutr Metab. 2007;51(3):208-15. doi: 10.1159/000104139. Epub 2007 Jun 18.
To assess the results of factor analysis of coronary artery disease risk factors in a large national representative sample of children, and to compare its results on the variables measured between those with or without metabolic syndrome (MetS).
This cross-sectional multicenter population survey was conducted on 4,811 nationally representative school students aged 6-18 years. MetS was defined based on criteria analogous to the Adult Treatment Panel III. Factor analysis by principle components analysis and Varimax rotation was carried out to cluster risk factors.
MetS was present in 14.1% of subjects (n = 678). From the nine variables assessed, factor analysis of the z scores of variables show that in all age groups, three similar factors were loaded: lipids, adiposity, and blood pressure, that accounted for 87.4-90.8% of the variance. Three factors were loaded in those with MetS (cholesterol/TG, metabolic/adiposity, and blood pressure) (65.9% of variance); and four factors (cholesterol, metabolic, adiposity, and blood pressure) were loaded among those without the MetS (75.6% of variance). We did not find a central feature that underlies all three factors among children with the MetS; however, waist circumference was the only variable that was loaded for two factors.
These findings support a change in the concept of MetS from that of a single entity to one that represents several distinct but intercorrelated entities. An approach to assessing risk clustering from early life, and longitudinal studies that would elucidate how these various risk domains interact over time are needed.
评估在一个具有全国代表性的大型儿童样本中对冠状动脉疾病风险因素进行因子分析的结果，并比较其在有或无代谢综合征（MetS）的儿童中所测量变量的结果。
对4811名年龄在6至18岁、具有全国代表性的在校学生进行了这项横断面多中心人群调查。MetS是根据类似于成人治疗小组III的标准定义的。通过主成分分析和方差最大化旋转进行因子分析，以对风险因素进行聚类。
14.1%的受试者（n = 678）存在MetS。从所评估的九个变量来看，对变量的z分数进行因子分析表明，在所有年龄组中，有三个相似的因子被提取出来：脂质、肥胖和血压，它们占方差的87.4 - 90.8%。MetS患者中有三个因子被提取出来（胆固醇/甘油三酯、代谢/肥胖和血压）（占方差的65.9%）；而无MetS的患者中有四个因子（胆固醇、代谢、肥胖和血压）被提取出来（占方差的75.6%）。我们在患有MetS的儿童中未发现构成所有三个因子基础的核心特征；然而，腰围是唯一一个在两个因子中被提取出来的变量。
这些发现支持将MetS的概念从单一实体转变为代表几个不同但相互关联实体的概念。需要一种从生命早期评估风险聚类的方法，以及能够阐明这些不同风险领域如何随时间相互作用的纵向研究。
