Retnakaran Ravi, Zinman Bernard, Connelly Philip W, Harris Stewart B, Hanley Anthony J G
Division of Endocrinology, the Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
J Pediatr. 2006 Feb;148(2):176-82. doi: 10.1016/j.jpeds.2005.08.025.
To study the relationships between nontraditional cardiovascular (CV) risk factors and components of the metabolic syndrome in Native Canadian children, a population at risk of future CV disease.
CV risk factors were evaluated in a population-based study of a Canadian Oji-Cree community, involving 236 children aged 10 to 19 years.
Using an age- and sex-specific case definition, 18.6% of the children met criteria for pediatric metabolic syndrome. As the number of metabolic syndrome component criteria increased, C-reactive protein, leptin, and ratio of apolipoprotein B to apolipoprotein A1 levels rose (all P < .0001) and adiponectin concentration decreased (P = .0006). Principal factor analysis using both traditional and nontraditional CV risk factors revealed 5 underlying core traits, defined as follows: adiposity, lipids/adiponectin, inflammation, blood pressure, and glucose.
Nontraditional CV risk factors accompany the accrual of traditional risk factors early in the progression to pediatric metabolic syndrome. Furthermore, inclusion of these factors in factor analysis suggests that 5 core traits underlie the early development of an enhanced CV risk factor profile in Native children.
在加拿大原住民儿童（一个未来有患心血管疾病风险的人群）中研究非传统心血管（CV）危险因素与代谢综合征各组分之间的关系。
在一项基于人群的加拿大奥吉 - 克里社区研究中，对236名10至19岁儿童的心血管危险因素进行了评估。
采用年龄和性别特异性病例定义，18.6%的儿童符合儿童代谢综合征标准。随着代谢综合征组分标准数量的增加，C反应蛋白、瘦素以及载脂蛋白B与载脂蛋白A1的比值升高（均P < .0001），而脂联素浓度降低（P = .0006）。使用传统和非传统心血管危险因素进行主成分分析，揭示了5个潜在的核心特征，定义如下：肥胖、脂质/脂联素、炎症、血压和血糖。
在儿童代谢综合征进展早期，非传统心血管危险因素伴随传统危险因素的累积出现。此外，在主成分分析中纳入这些因素表明，5个核心特征是原住民儿童心血管危险因素增强早期发展的基础。
